Abstract:
Cardiovascular disease is a major health problem in developed and developing countries and still be the first rank
causing death n the world, including Indonesia. M o s t of cardiovascular disease caused by atherosclerosis. Macrophage
apoptosis can reduce the size of atherogenic lesions and the progression of atherosclerotic plaque formation. Proapopstosis
effects on macrophages owned by flavonoids. This study aims to know the potential of flavonoids found in Citrus grandis
extract which works by suppressing the phosphorylation of AKT Ser473 so that the formation of foam cells (foam call) can be
minimized. The research sample is 38 male Wistar rats weighing 90-150 grams. Samples were divided into 5 groups. All
groups except normal control group were induced atherosclerosis by utilizing the shear stress mechanism at the branch of
the abdominal aorta. Shear stress created by injecting adrenaline i.v. followed by hyperlipidemic diet (egg yolk) for 3 weeks.
Then, during the next two weeks, the positive control group treated with simvastatin, while the treatment group were treated
with extracts of C. grandis (ECG) known to contains flavonoids. Macroscopic showed that ECG could reduce atherosclerotic
lesions. of citrus grandis. The sample data captured in the form of mouse blood and abdominal aortic tissues. Based on the
results of the TLC screening, Ethanolic Extrxct Meanwhile, the group given simvastatin as a positive control also showed
fewer atherosclerotic lesions. ECG proven to lower cholesterol and triglyceride levels of rats t h a t had been induced
atherosclerosis. Award ECG doses of 500 and 1000 mg/kg showed a significant decrease in cholesterol (p <0.01) compared
to the negative control group. ECG is proven to reduce atherosclerotic lesions, so that ECG can be used as an adjuvant for
simvastatin to achieve maximal therapeutic effect against atherosclerosis.
Description:
Proceeding The 1
IBSC: Towards The Extended Use Of Basic Science For Enhancing
Health, Environment, Energy And Biotechnology